Project Caboodle explores the acceptability and feasibility of self-collecting at home and returning by mail all, some, or none of the following five biological specimens: (i) finger-stick blood sample, (ii) pharyngeal swab, (iii) urine specimen, (iv) rectal swab, and (v) hair sample, among 100 high-risk, HIV-negative or unknown status US MSM (18-34 years, 50 black and 50 white) recruited through social networking websites and mobile gay dating apps.

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A second phase of in-depth interviews from a sample of participants will collect qualitative data about participant's experiences in the study.